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It is very important to address any gut issues that may be prevalent prior to addressing the CBS defect

Long-term (180-Day) outcomes in critically ill patients with COVID-19 in the REMAP-CAP randomized clinical trial

Agmon E, Solon J, Bassereau P, Stockwell BR

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Thus, even under constitutive Notch activation a subset of transformed glioma cells can re-enter the cell cycle and promote tumor growth, similar to subpopulations of persister cells identified in other cancer types (Oren et al, 2021)